Pre_GI Gene

Some Help

Host: NC_010117 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010117:700112 Coxiella burnetii RSA 331, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain (RSA 331; Hentzerling) is associated with acute Q fever and was isolated from the blood of an infected patient in northern Italy in 1945. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6991037001371035NAD dependent epimerasedehydratase family proteinQuickGO ontologyBLASTP
7001127016921581putative ADP-heptose synthaseQuickGO ontologyBLASTP
701695702639945oxidoreductase NAD-bindingQuickGO ontologyBLASTP
7026247039341311UDP-glucoseGDP-mannose dehydrogenase family proteinQuickGO ontologyBLASTP
703927704832906NAD-dependent epimerasedehydratase family proteinQuickGO ontologyBLASTP
704835705488654putative methyltransferaseQuickGO ontologyBLASTP
7054857066721188methyltransferase FkbM familyQuickGO ontologyBLASTP
7070867085041419sulfotransferase domain proteinQuickGO ontologyBLASTP
7089497122723324hypothetical proteinBLASTP
712503713210708pyruvate dehydrogenase acetyl-transferring E1 component alphabeta fusion proteinQuickGO ontologyBLASTP
7132277148701644putative membrane proteinQuickGO ontologyBLASTP
715250716248999GDP-L-fucose synthaseQuickGO ontologyBLASTP
7162417172871047GDP-mannose 46-dehydrataseQuickGO ontologyBLASTP
717314718153840glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
7181467193841239NDP-hexose 3-C-methyltransferase TylCIIIQuickGO ontologyBLASTP
7194057204661062putative pyruvate dehydrogenase acetyl-transferring E1 component beta subunitQuickGO ontologyBLASTP
7204637214881026putative pyruvate dehydrogenase acetyl-transferring E1 component alpha subunitQuickGO ontologyBLASTP
7216397227511113glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
7228137241891377hypothetical proteinBLASTP
7241827253301149DegTDnrJEryC1StrS aminotransferase family proteinQuickGO ontologyBLASTP
7253677265271161DegTDnrJEryC1StrS aminotransferase family proteinQuickGO ontologyBLASTP
7265507277191170hypothetical proteinBLASTP