Pre_GI Gene

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Host: NC_010117 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010117:285230 Coxiella burnetii RSA 331, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain (RSA 331; Hentzerling) is associated with acute Q fever and was isolated from the blood of an infected patient in northern Italy in 1945. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2852302893574128DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
289304289555252hypothetical proteinBLASTP
2896252938694245DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
294054294326273hypothetical proteinBLASTP
2943232953421020transposase for insertion sequence element IS1111AQuickGO ontologyBLASTP
295585295959375ribosomal protein S12QuickGO ontologyBLASTP
295972296547576ribosomal protein S7QuickGO ontologyBLASTP
2965572986562100translation elongation factor GQuickGO ontologyBLASTP
2986722998651194translation elongation factor TuQuickGO ontologyBLASTP
300055300387333ribosomal protein S10QuickGO ontologyBLASTP
300409301062654ribosomal protein L3QuickGO ontologyBLASTP
301062301679618ribosomal protein L4QuickGO ontologyBLASTP
301676301963288ribosomal protein L23QuickGO ontologyBLASTP
301983302810828ribosomal protein L2QuickGO ontologyBLASTP
302823303110288ribosomal protein S19QuickGO ontologyBLASTP
303110303457348ribosomal protein L22QuickGO ontologyBLASTP
303457304140684ribosomal protein S3QuickGO ontologyBLASTP
304152304565414ribosomal protein L16QuickGO ontologyBLASTP
304566304763198ribosomal protein L29QuickGO ontologyBLASTP
304756305025270ribosomal protein S17QuickGO ontologyBLASTP
305036305404369ribosomal protein L14QuickGO ontologyBLASTP
305416305739324ribosomal protein L24QuickGO ontologyBLASTP
305856306404549ribosomal protein L5QuickGO ontologyBLASTP
306409306708300ribosomal protein S14QuickGO ontologyBLASTP
306711307103393ribosomal protein S8QuickGO ontologyBLASTP