Pre_GI Gene

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Host: NC_010117 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010117:1461502 Coxiella burnetii RSA 331, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: This strain (RSA 331; Hentzerling) is associated with acute Q fever and was isolated from the blood of an infected patient in northern Italy in 1945. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14615021462431930tRNA pseudouridine synthase BQuickGO ontologyBLASTP
14624091462768360ribosome-binding factor AQuickGO ontologyBLASTP
146285614652672412translation initiation factor IF-2QuickGO ontologyBLASTP
146527314667841512transcription termination factor NusAQuickGO ontologyBLASTP
14667881467249462conserved hypothetical proteinBLASTP
146762714690751449NADH dehydrogenase ubiquinone N subunitQuickGO ontologyBLASTP
146908514706051521NADH dehydrogenase ubiquinone M subunitQuickGO ontologyBLASTP
147061014725711962NADH dehydrogenase ubiquinone L subunitQuickGO ontologyBLASTP
14726281472933306NADH dehydrogenase ubiquinone K subunitQuickGO ontologyBLASTP
14729301473535606NADH dehydrogenase ubiquinone J subunitQuickGO ontologyBLASTP
14735491474040492NADH dehydrogenase ubiquinone I subunitQuickGO ontologyBLASTP
147403714750591023NADH dehydrogenase ubiquinone H subunitQuickGO ontologyBLASTP
147505914774222364NADH dehydrogenase ubiquinone G subunitQuickGO ontologyBLASTP
14774331477552120hypothetical proteinBLASTP
147753314788011269NADH dehydrogenase ubiquinone F subunitQuickGO ontologyBLASTP
14787911479315525NADH dehydrogenase ubiquinone E subunitQuickGO ontologyBLASTP
147931514805681254NADH dehydrogenase ubiquinone D subunitQuickGO ontologyBLASTP
14805611481244684NADH dehydrogenase ubiquinone C subunitQuickGO ontologyBLASTP
14812541481739486NADH dehydrogenase ubiquinone B subunitQuickGO ontologyBLASTP
14817441482100357NADH dehydrogenase ubiquinone A subunitQuickGO ontologyBLASTP
14823971482693297preprotein translocase SecG subunitQuickGO ontologyBLASTP
14826751483442768triose-phosphate isomeraseQuickGO ontologyBLASTP
14835081483639132hypothetical protein