Pre_GI Gene

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Host: NC_009882 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009882:563830 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
563830564159330hypothetical proteinBLASTP
565725565901177hypothetical proteinBLASTP
5672795682981020capM proteinQuickGO ontologyBLASTP
568302568589288hypothetical proteinBLASTP
569277570089813diaminopimelate epimeraseQuickGO ontologyBLASTP
5700645713291266hypothetical proteinBLASTP
5715715726201050phenylalanyl-tRNA synthetase subunit alphaQuickGO ontologyBLASTP
5726175750732457phenylalanyl-tRNA synthetase subunit betaQuickGO ontologyBLASTP
5750785762171140DNA polymerase III subunit betaQuickGO ontologyBLASTP
576573577076504hypothetical proteinBLASTP
5772055797122508leucyl-tRNA synthetaseQuickGO ontologyBLASTP
580231580386156hypothetical proteinBLASTP
580790581401612ribonuclease DQuickGO ontologyBLASTP
581550581855306hypothetical proteinBLASTP
581852582544693phosphatidate cytidylyltransferaseQuickGO ontologyBLASTP
582504583184681undecaprenyl pyrophosphate synthetaseQuickGO ontologyBLASTP
5833575847871431osmolarity sensor protein envZQuickGO ontologyBLASTP
584771585451681petR proteinQuickGO ontologyBLASTP
585663586535873branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP