Pre_GI Gene

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Host: NC_009882 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009882:278384 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2783842811012718DNA gyrase subunit AQuickGO ontologyBLASTP
281627281836210hypothetical protein
281923282165243TransporterQuickGO ontologyBLASTP
282877282996120hypothetical proteinBLASTP
283121283303183hypothetical proteinBLASTP
283330283482153peptide deformylaseQuickGO ontologyBLASTP
283754284281528peptide deformylaseQuickGO ontologyBLASTP
284293285189897methionyl-tRNA formyltransferaseQuickGO ontologyBLASTP
285406285849444hypothetical proteinBLASTP
2891092892271195S ribosomal RNAQuickGO ontologyBLASTP
289631290197567hypothetical proteinBLASTP
2903562914081053putative ATPase n2BQuickGO ontologyBLASTP
2916232927201098S-adenosylmethioninetRNA ribosyltransferase-isomeraseQuickGO ontologyBLASTP
292887293315429hypothetical proteinBLASTP
293486293725240hypothetical proteinBLASTP
293809293943135hypothetical proteinBLASTP
2940172957861770multidrug resistance ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
295966296238273hypothetical proteinBLASTP