Pre_GI Gene

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Host: NC_009882 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009882:13826 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1382614749924hypothetical proteinBLASTP
1483514990156hypothetical proteinBLASTP
1499815525528hypothetical proteinBLASTP
1551316217705zincmanganese ABC transporter substrate binding proteinQuickGO ontologyBLASTP
16463177731311polyA polymeraseQuickGO ontologyBLASTP
1826318487225hypothetical proteinBLASTP
1857219300729hypothetical proteinBLASTP
1932119467147hypothetical proteinBLASTP
1966519781117hypothetical proteinBLASTP
20197257975601cell surface antigenQuickGO ontologyBLASTP
259072598175tRNA-GluQuickGO ontology
2605326181129hypothetical proteinBLASTP
2654326668126hypothetical proteinBLASTP
2711327853741hypothetical proteinBLASTP
2782028053234Tetratricopeptide repeat-containing proteinQuickGO ontologyBLASTP
2819428376183hypothetical proteinBLASTP
2870829202495F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2920229675474F0F1 ATP synthase subunit BQuickGO ontologyBLASTP
2969429912219F0F1 ATP synthase subunit CQuickGO ontologyBLASTP
3011430842729F0F1 ATP synthase subunit AQuickGO ontologyBLASTP
3084731143297hypothetical proteinBLASTP
3122132054834hypothetical proteinBLASTP
3221832739522hypothetical proteinBLASTP
32986345901605hypothetical proteinBLASTP
3471334922210recombination protein FQuickGO ontologyBLASTP
35019361011083recombination protein FQuickGO ontologyBLASTP