Pre_GI Gene

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Host: NC_009882 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009882:1123709 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11237091124188480NADH dehydrogenase subunit IQuickGO ontologyBLASTP
112437511253941020NADH dehydrogenase subunit HQuickGO ontologyBLASTP
112551611275462031NADH dehydrogenase subunit GQuickGO ontologyBLASTP
11275341127890357hypothetical proteinBLASTP
112805911306952637aconitate hydrataseQuickGO ontologyBLASTP
11308771131215339F0F1 ATP synthase subunit epsilonQuickGO ontologyBLASTP
113127311326941422F0F1 ATP synthase subunit betaQuickGO ontologyBLASTP
11328671133838972F0F1 ATP synthase subunit gammaQuickGO ontologyBLASTP
113397211355041533F0F1 ATP synthase subunit alphaQuickGO ontologyBLASTP
11356701136224555F0F1 ATP synthase subunit deltaQuickGO ontologyBLASTP
113638811377671380dihydrolipoamide dehydrogenaseQuickGO ontologyBLASTP
11379221138350429Strees induced DNA-binding proteinQuickGO ontologyBLASTP
11385471138807261hypothetical proteinBLASTP
11390181139221204hypothetical proteinBLASTP
11393091139425117hypothetical protein
11396841139986303hypothetical proteinBLASTP
11401251140397273hypothetical proteinBLASTP
114082911432012373penicillin-binding protein 1aQuickGO ontologyBLASTP
114320511445421338hypothetical proteinBLASTP
11452971145404108hypothetical protein
11458151145958144hypothetical protein
11459981146147150hypothetical proteinBLASTP