Pre_GI Gene

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Host: NC_009882 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009882:100000 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
100236100796561hypothetical proteinBLASTP
1008511022481398NADp transhydrogenase subunit betaQuickGO ontologyBLASTP
102387103121735hypothetical outer-membrane proteinQuickGO ontologyBLASTP
103276104160885hypothetical proteinBLASTP
1041471054031257prolinebetaine transporterQuickGO ontologyBLASTP
105400105576177hypothetical proteinBLASTP
105684105884201hypothetical proteinBLASTP
10598410605875tRNA-ThrQuickGO ontology
106238106540303preprotein translocase subunit SecGQuickGO ontologyBLASTP
1074471129125466190 kD antigen precursorQuickGO ontologyBLASTP
1132091145881380cysteinyl-tRNA synthetaseQuickGO ontologyBLASTP
11482911571688830S ribosomal protein S2QuickGO ontologyBLASTP
115915116844930elongation factor TsQuickGO ontologyBLASTP
117318117707390hypothetical proteinBLASTP
118077118205129hypothetical proteinBLASTP
11835411974813953-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
119745120401657hypothetical proteinBLASTP
1205521217571206aspartate aminotransferaseQuickGO ontologyBLASTP