Pre_GI Gene

Some Help

Host: NC_009727 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009727:766000 Coxiella burnetii Dugway 7E9-12, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
766318766698381hypothetical protein
767345767575231hypothetical proteinBLASTP
767680768105426hypothetical protein
7685357699801446serine carboxypeptidaseQuickGO ontologyBLASTP
770496770657162hypothetical protein
770661770870210hypothetical protein
772260773033774hypothetical protein
772997773647651hypothetical protein
7736927750021311polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
7754127785073096hypothetical protein
778727778882156hypothetical proteinBLASTP
779117779602486hypothetical proteinBLASTP
7796537820642412copper-resistance protein CopA family proteinQuickGO ontologyBLASTP
7820787846272550NAD-dependent epimerasedehydratase familyvitamin K epoxide reductase family proteinQuickGO ontologyBLASTP
784726785052327quaternary ammonium compound-resistance protein qacEQuickGO ontologyBLASTP
786139786726588hypothetical protein
787082787372291hypothetical protein
787590787940351hypothetical protein
7880997892921194major facilitator family transporterQuickGO ontologyBLASTP