Pre_GI Gene

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Host: NC_009727 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009727:670616 Coxiella burnetii Dugway 7E9-12, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
669687670631945oxidoreductase NAD-bindingQuickGO ontologyBLASTP
6706166719261311UDP-glucoseGDP-mannose dehydrogenase family proteinQuickGO ontologyBLASTP
671919672824906NAD-dependent epimerasedehydratase family proteinQuickGO ontologyBLASTP
672827673480654putative methyltransferaseQuickGO ontologyBLASTP
6734776746641188methyltransferase FkbM familyQuickGO ontologyBLASTP
674661674777117hypothetical protein
6750786764961419sulfotransferase domain proteinQuickGO ontologyBLASTP
6769416802793339hypothetical proteinBLASTP
680510681220711pyruvate dehydrogenase acetyl-transferring E1 component alphabeta fusion proteinQuickGO ontologyBLASTP
6812376828801644hypothetical proteinBLASTP
683260684258999GDP-L-fucose synthaseQuickGO ontologyBLASTP
6842516852971047GDP-mannose 46-dehydrataseQuickGO ontologyBLASTP
685324686163840glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
6861566873941239NDP-hexose 3-C-methyltransferase TylCIIIQuickGO ontologyBLASTP
6874156884761062putative pyruvate dehydrogenase acetyl-transferring E1 component beta subunitQuickGO ontologyBLASTP
6884736894981026putative pyruvate dehydrogenase acetyl-transferring E1 component alpha subunitQuickGO ontologyBLASTP
6896496907611113glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
6908236921991377hypothetical proteinBLASTP
6921926933401149DegTDnrJEryC1StrS aminotransferase family proteinQuickGO ontologyBLASTP