Pre_GI Gene

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Host: NC_009727 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009727:357206 Coxiella burnetii Dugway 7E9-12, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
357206357622417IcmD proteinQuickGO ontologyBLASTP
357638358273636IcmJ proteinQuickGO ontologyBLASTP
3583463613573012IcmB proteinQuickGO ontologyBLASTP
361372361509138hypothetical proteinBLASTP
361727362272546hypothetical proteinBLASTP
3629733641901218hypothetical proteinBLASTP
364449364727279hypothetical proteinBLASTP
364828365088261hypothetical protein
3652973679722676ankyrin repeat proteinQuickGO ontologyBLASTP
368308368706399hypothetical proteinBLASTP
3691063712022097transporter small conductance mechanosensitive ion channel MscS family proteinQuickGO ontologyBLASTP
3713573723851029succinylglutamate desuccinylaseaspartoacylase family proteinQuickGO ontologyBLASTP
372388373293906ribosomal protein S6 modification proteinQuickGO ontologyBLASTP
373290373712423hypothetical proteinBLASTP
373792373950159hypothetical protein
374133374678546opacity family porin proteinQuickGO ontologyBLASTP
37474437482077tRNA-MetQuickGO ontology
374836375639804hypothetical protein
3757063770251320hypothetical protein
3772503793462097RNA polymerase sigma factor RpoDQuickGO ontologyBLASTP