Pre_GI Gene

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Host: NC_009727 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009727:1899876 Coxiella burnetii Dugway 7E9-12, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18991211899879759ABC transporter quaternary amine uptake transporter QAT family ATP-binding proteinQuickGO ontologyBLASTP
189987619014561581ABC transporter quaternary amine uptake transporter QAT family permeaseperiplasmic amine-binding proteinQuickGO ontologyBLASTP
190146519026521188trypsin domain proteinQuickGO ontologyBLASTP
19027171903457741serinethreonine-protein kinase pkn2QuickGO ontologyBLASTP
19035941904043450hypothetical protein
19041611904613453hypothetical protein
190499219062391248hypothetical protein
19062391906517279putative polyketide biosynthesis acyl carrier proteinQuickGO ontologyBLASTP
190728319085211239hydroxymethylglutaryl-CoA synthaseQuickGO ontologyBLASTP
190852819097631236beta-ketoacyl synthaseQuickGO ontologyBLASTP
191314419169863843non-ribosomal peptide synthetaseQuickGO ontologyBLASTP
191736119183711011hypothetical protein
19186201919084465hypothetical protein
19195661919697132hypothetical protein
19196511920607957oxidoreductase aldoketo reductase family proteinQuickGO ontologyBLASTP