Pre_GI Gene

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Host: NC_009727 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009727:1822877 Coxiella burnetii Dugway 7E9-12, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18228771823308432ribosomal protein L15QuickGO ontologyBLASTP
18233111823502192ribosomal protein L30QuickGO ontologyBLASTP
18235061824012507ribosomal protein S5QuickGO ontologyBLASTP
18240241824377354ribosomal protein L18QuickGO ontologyBLASTP
18243771824913537ribosomal protein L6QuickGO ontologyBLASTP
18249511825343393ribosomal protein S8QuickGO ontologyBLASTP
18253461825645300ribosomal protein S14QuickGO ontologyBLASTP
18256501826198549ribosomal protein L5QuickGO ontologyBLASTP
18263151826638324ribosomal protein L24QuickGO ontologyBLASTP
18266501827018369ribosomal protein L14QuickGO ontologyBLASTP
18270291827298270ribosomal protein S17QuickGO ontologyBLASTP
18272911827488198ribosomal protein L29QuickGO ontologyBLASTP
18274891827902414ribosomal protein L16QuickGO ontologyBLASTP
18279141828597684ribosomal protein S3QuickGO ontologyBLASTP
18285971828944348ribosomal protein L22QuickGO ontologyBLASTP
18289441829231288ribosomal protein S19QuickGO ontologyBLASTP
18292441830071828ribosomal protein L2QuickGO ontologyBLASTP
18300911830378288ribosomal protein L23QuickGO ontologyBLASTP
18303751830992618ribosomal protein L4QuickGO ontologyBLASTP
18309921831645654ribosomal protein L3QuickGO ontologyBLASTP
18316671831999333ribosomal protein S10QuickGO ontologyBLASTP
183218918333821194translation elongation factor TuQuickGO ontologyBLASTP
183339818354972100translation elongation factor GQuickGO ontologyBLASTP
18355071836082576ribosomal protein S7QuickGO ontologyBLASTP
18360951836469375ribosomal protein S12QuickGO ontologyBLASTP
183681218410564245DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
18411501841284135hypothetical proteinBLASTP
184132518454524128DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
18456051845985381ribosomal protein L7L12QuickGO ontologyBLASTP
18460191846543525ribosomal protein L10QuickGO ontologyBLASTP