Pre_GI Gene

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Host: NC_009727 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009727:1177390 Coxiella burnetii Dugway 7E9-12, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii Dugway 5J108-111 was isolated from rodents in Utah, USA. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
117739011784361047hypothetical protein
117843711797141278transglycosylase Slt familyQuickGO ontologyBLASTP
118102211824161395hypothetical protein
11823991182527129hypothetical protein
118250111864033903hypothetical proteinBLASTP
118651111896333123hypothetical proteinBLASTP
118975511909571203membrane-bound lytic murein transglycosylase family proteinQuickGO ontologyBLASTP
11909391191226288GIY-YIG catalytic domain proteinQuickGO ontologyBLASTP
11914261191986561hypothetical protein
11920831192646564hypothetical protein
11928301193075246hypothetical protein
119307611941851110alanine dehydrogenaseQuickGO ontologyBLASTP
11942141195158945electron transfer flavoprotein alpha subunitQuickGO ontologyBLASTP
11951551195907753electron transfer flavoprotein beta subunitQuickGO ontologyBLASTP
11959041196617714dienelactone hydrolase family proteinQuickGO ontologyBLASTP
119674811983731626electron-transferring-flavoprotein dehydrogenaseQuickGO ontologyBLASTP
11983681198550183hypothetical protein
11985811199339759enhanced entry protein EnhAQuickGO ontology
11995751200516942curved DNA-binding proteinQuickGO ontologyBLASTP