Pre_GI Gene

Some Help

Host: NC_009699 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009699:1 Clostridium botulinum F str. Langeland chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum F strain Langeland was identified in 1958 from home-prepared liver paste involved in an outbreak of foodborne botulism on the island of Langeland, in Denmark. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
113381338chromosomal replication initiation proteinQuickGO ontologyBLASTP
160127041104DNA polymerase III subunit betaQuickGO ontologyBLASTP
27232929207S4 domain-containing proteinQuickGO ontologyBLASTP
300841021095recombination protein FQuickGO ontologyBLASTP
41234386264hypothetical proteinBLASTP
440463171914DNA gyrase subunit BQuickGO ontologyBLASTP
634388382496DNA gyrase subunit AQuickGO ontologyBLASTP
89359051117hypothetical proteinBLASTP
13907140231175S ribosomal RNAQuickGO ontologyBLASTP
141111418878tRNA-AlaQuickGO ontologyBLASTP
141121418776tRNA-AlaQuickGO ontologyBLASTP
1438214804423hypothetical proteinBLASTP
1482015341522transcriptional regulatorQuickGO ontologyBLASTP
15343165061164Fe-S-binding proteinQuickGO ontologyBLASTP
16511191922682hypothetical proteinBLASTP