Pre_GI Gene

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Host: NC_009697 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009697:2790277 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
279027727916981422glycosyl transferase family proteinQuickGO ontologyBLASTP
27917072792054348hypothetical proteinBLASTP
279205827937611704hypothetical proteinBLASTP
279378627956871902glycosyl transferase family proteinQuickGO ontologyBLASTP
27959102796737828flagellinQuickGO ontologyBLASTP
27969512797778828flagellinQuickGO ontologyBLASTP
27979282798269342hypothetical proteinBLASTP
279829628007312436flagellar hook-associated protein 2QuickGO ontologyBLASTP
28007852801174390flagellar protein FliSQuickGO ontologyBLASTP
28012112801510300hypothetical proteinBLASTP
28015652801921357flagellar protein FlaGQuickGO ontologyBLASTP
28019372802155219carbon storage regulatorQuickGO ontologyBLASTP
28021552802586432flagellar assembly protein FliWQuickGO ontologyBLASTP
28026752803637963flagellar hook-associated protein 3QuickGO ontologyBLASTP
280365528055231869flagellar hook-associated protein FlgKQuickGO ontologyBLASTP
28058122806216405flgN family proteinQuickGO ontologyBLASTP
28062162806497282regulator of flagellin synthesis FlgMQuickGO ontologyBLASTP
280699428081541161flagellar motor switch proteinQuickGO ontologyBLASTP
28081472809142996flagellar motor switch protein FliMQuickGO ontologyBLASTP
28091702809565396chemotaxis protein CheWQuickGO ontologyBLASTP
28096652810024360chemotaxis protein CheYQuickGO ontologyBLASTP
28100522810651600chemotaxis protein CheCQuickGO ontologyBLASTP
281067728127522076chemotaxis protein CheAQuickGO ontologyBLASTP
28127652813535771chemotaxis protein methyltransferase CheRQuickGO ontologyBLASTP
281355028146141065protein-glutamate methylesterase CheBQuickGO ontologyBLASTP
28146372815125489chemoreceptor glutamine deamidase CheDQuickGO ontologyBLASTP
28151422815588447chemotaxis protein CheWQuickGO ontologyBLASTP
281560428176372034hypothetical proteinBLASTP
281789028198451956PTS system glucose family transporter subunit IIABCQuickGO ontologyBLASTP