Pre_GI Gene

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Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:477093 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
477093477563471hypothetical proteinBLASTP
477989478630642putative secreted proteinQuickGO ontologyBLASTP
4786374798661230putative conserved lipoprotein LpqKQuickGO ontologyBLASTP
4798764810631188putative glutaryl-CoA dehydrogenaseQuickGO ontologyBLASTP
481099481470372putative conserved transmembrane proteinQuickGO ontologyBLASTP
4816654845412877transmembrane transport protein MmpL1QuickGO ontologyBLASTP
484538484966429putative conserved membrane protein MmpS1QuickGO ontologyBLASTP
4852874870441758fatty-acid-CoA ligase FadD30QuickGO ontologyBLASTP
4870414912494209membrane bound polyketide synthase Pks6QuickGO ontologyBLASTP
491197492015819beta lactamase like proteinQuickGO ontologyBLASTP
4920934931031011putative f420-dependent glucose-6-phosphate dehydrogenase Fgd1QuickGO ontologyBLASTP
4930964951682073phosphate acetyltransferaseQuickGO ontologyBLASTP
4951614963181158acetatepropionate kinaseQuickGO ontologyBLASTP
4963724986242253serinethreonine protein kinaseQuickGO ontologyBLASTP
498624499610987amino acid ABC transporter substrate-binding proteinQuickGO ontologyBLASTP
4996105009291320putative conserved membrane proteinQuickGO ontologyBLASTP