Pre_GI Gene

Some Help

Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:3484924 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34840083484934927putative conserved transmembrane proteinQuickGO ontologyBLASTP
348492434860601137peptide chain release factor 2QuickGO ontologyBLASTP
348616334875331371ferredoxin--NADP reductaseQuickGO ontologyBLASTP
348753434891171584alkyldihydroxyacetonephosphate synthase AgpSQuickGO ontologyBLASTP
34892163489656441hypothetical proteinBLASTP
348980534908841080molybdenum cofactor biosynthesis protein A1QuickGO ontologyBLASTP
34909353491330396pterin-4-alpha-carbinolamine dehydratase MoaB1QuickGO ontologyBLASTP
34913273491839513molybdenum cofactor biosynthesis protein C1QuickGO ontologyBLASTP
34918563492107252molybdenum cofactor biosynthesis protein D1QuickGO ontologyBLASTP
34922303492898669haloacid dehalogenase-like family hydrolaseQuickGO ontologyBLASTP
34929153493445531hypothetical proteinBLASTP
349360734948541248IS1081 transposaseQuickGO ontologyBLASTP
349493234961011170molybdenum cofactor biosynthesis protein MoeB2QuickGO ontologyBLASTP
34961303496963834thiosulfate sulfurtransferase CysA3QuickGO ontologyBLASTP
34969653497267303conserved hypothetical protein SseC1QuickGO ontologyBLASTP
34972883497731444molybdenum cofactor biosynthesis protein E1QuickGO ontologyBLASTP
34977283498330603hypothetical proteinBLASTP
349866534998671203putative cytochrome p450 141 CYP141QuickGO ontologyBLASTP
35002453500715471hypothetical proteinBLASTP
35007253501219495hypothetical proteinBLASTP
35016623502531870putative transcriptional regulatory proteinQuickGO ontologyBLASTP
350263235038071176PPE family proteinQuickGO ontologyBLASTP
35039643504278315hypothetical proteinBLASTP
350430335053371035hypothetical proteinBLASTP