Pre_GI Gene

Some Help

Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:2802987 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
280124828029901743bifunctional transmembrane phospholipid biosynthesis enzyme PlsCQuickGO ontologyBLASTP
280298728044621476hypothetical proteinBLASTP
280469128059561266carboxylesterase LipQQuickGO ontologyBLASTP
28063182807088771enoyl-CoA hydratase EchA14QuickGO ontologyBLASTP
280726928093532085PE-PGRS family proteinQuickGO ontologyBLASTP
280943528128483414LuxR family transcriptional regulatorQuickGO ontologyBLASTP
28128142813113300hypothetical alanine rich proteinQuickGO ontologyBLASTP
281322228182044983PE-PGRS family proteinQuickGO ontologyBLASTP
28182912818497207hypothetical proteinBLASTP
28186332819256624hypothetical proteinBLASTP
28192462819998753hypothetical proteinBLASTP
28200512820272222hypothetical proteinBLASTP
28202782820703426hypothetical proteinBLASTP
282072628219071182dihydrolipoamide S-acetyltransferase E2 component PdhCQuickGO ontologyBLASTP
282190428229501047putative 2-oxoisovalerate dehydrogenase E1 component subunit betaQuickGO ontologyBLASTP
282296128240641104putative 2-oxoisovalerate dehydrogenase E1 component subunit alphaQuickGO ontologyBLASTP
28243232825144822citrate lyase subunit betaQuickGO ontologyBLASTP
28251412825698558putative oxidase regulatory-related proteinQuickGO ontologyBLASTP
282569528268791185acyl-CoA dehydrogenase FadE19QuickGO ontologyBLASTP