Pre_GI Gene

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Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:2635792 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
26357922636076285putative esat-6 like protein EsxOQuickGO ontologyBLASTP
26361272636423297putative esat-6 like protein EsxPQuickGO ontologyBLASTP
26365582636884327hypothetical proteinBLASTP
263707626386021527phospholipase C 3 PlcCQuickGO ontologyBLASTP
263868526402231539membrane-associated phospholipase C 2QuickGO ontologyBLASTP
264044126419791539membrane-associated phospholipase C 1QuickGO ontologyBLASTP
26424692642696228hypothetical proteinBLASTP
264282726440021176PPE family proteinQuickGO ontologyBLASTP
26442042644488285putative esat-6 like proteinQuickGO ontologyBLASTP
26445032644826324putative esat-6 like proteinQuickGO ontologyBLASTP
264489126460661176PPE family proteinQuickGO ontologyBLASTP
264649626475601065PPE family proteinQuickGO ontologyBLASTP
26475962647922327IS6110 hypothetical proteinQuickGO ontologyBLASTP
26479732648857885IS6110 transposaseQuickGO ontologyBLASTP
264965626515031848PPE family proteinQuickGO ontologyBLASTP
265164126530321392glycyl-tRNA synthetaseQuickGO ontologyBLASTP
26532142653621408ArsR family transcriptional regulatorQuickGO ontologyBLASTP
26536182654010393ferric uptake regulation protein FurBQuickGO ontologyBLASTP
26541182654546429hypothetical proteinBLASTP
26545462655436891undecaprenyl diphosphate synthaseQuickGO ontologyBLASTP
26554292656226798DNA repair protein RecOQuickGO ontologyBLASTP
265628826577421455amidase AmiA2QuickGO ontologyBLASTP
26577392658641903GTP-binding protein EraQuickGO ontologyBLASTP