Pre_GI Gene

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Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:1872360 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18714401872363924ornithine carbamoyltransferaseQuickGO ontologyBLASTP
18723601872872513arginine repressorQuickGO ontologyBLASTP
187288118740771197argininosuccinate synthaseQuickGO ontologyBLASTP
187415718755691413argininosuccinate lyaseQuickGO ontologyBLASTP
187567818767391062putative chalcone synthase Pks10QuickGO ontologyBLASTP
187682218832026381putative polyketide synthase Pks7QuickGO ontologyBLASTP
188322218880304809putative polyketide synthase Pks8QuickGO ontologyBLASTP
188803018895381509putative polyketide synthase Pks17QuickGO ontologyBLASTP
188954418925973054putative polyketide synthase Pks9QuickGO ontologyBLASTP
189274418938051062putative chalcone synthase Pks11QuickGO ontologyBLASTP
189378818950801293putative cytochrome P450 139 CYP139QuickGO ontologyBLASTP
18950951895748654macrolide ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
189574218968601119macrolide ABC transporter ATP-binding proteinQuickGO ontologyBLASTP