Pre_GI Gene

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Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:1685522 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
168552216877742253putative methylmalonyl-COA mutase large subunit MutBQuickGO ontologyBLASTP
16877881688090303hypothetical proteinBLASTP
16880871688404318hypothetical proteinBLASTP
168840116894051005arginineornithine transport system ATPaseQuickGO ontologyBLASTP
168945816907471290putative esterase LipLQuickGO ontologyBLASTP
16908201691437618methyltransferaseQuickGO ontologyBLASTP
16916511691863213hypothetical proteinBLASTP
16919241692322399hypothetical proteinBLASTP
169236716933951029putative dolichol-phosphate mannosyltransferaseQuickGO ontologyBLASTP
16934071694228822hypothetical proteinBLASTP
16944411695340900hypothetical proteinBLASTP
16955131695953441hypothetical proteinBLASTP
16960621696661600hypothetical proteinBLASTP
16967981697463666hypothetical proteinBLASTP
16974601697960501hypothetical proteinBLASTP
16982441698939696hypothetical proteinBLASTP
169961217014111800hypothetical proteinBLASTP
17013831701745363hypothetical proteinBLASTP
17017291702610882hypothetical proteinBLASTP
170281217041101299hypothetical proteinBLASTP
170459117056131023GDP-D-mannose dehydrataseQuickGO ontologyBLASTP
17056101706578969fucose synthetaseQuickGO ontologyBLASTP
17065751707306732hypothetical proteinBLASTP
17073241708112789hypothetical proteinBLASTP
17081471709043897hypothetical proteinBLASTP
170904617100561011glycosyl transferaseQuickGO ontologyBLASTP
17103881711152765hypothetical proteinBLASTP