Pre_GI Gene

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Host: NC_009495 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009495:1 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
113471347chromosomal replication initiation proteinQuickGO ontologyBLASTP
161027131104DNA polymerase III subunit betaQuickGO ontologyBLASTP
27322938207S4 domain-containing proteinQuickGO ontologyBLASTP
299841011104recombination protein FQuickGO ontologyBLASTP
41224385264hypothetical proteinBLASTP
440363161914DNA gyrase subunit BQuickGO ontologyBLASTP
634288522511DNA gyrase subunit AQuickGO ontologyBLASTP
13982141071265S ribosomal RNAQuickGO ontologyBLASTP
141871426276tRNA-AlaQuickGO ontologyBLASTP
1442714879453hypothetical proteinBLASTP
1489515416522transcriptional regulatorQuickGO ontologyBLASTP
15517165811065Fe-S-binding proteinQuickGO ontologyBLASTP