Pre_GI Gene

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Host: NC_009494 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009494:775676 Legionella pneumophila str. Corby chromosome, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Legionella pneumophila str. Corby is a human isolate. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
775676776224549ATP-dependent protease peptidase subunitQuickGO ontologyBLASTP
7762087775511344ATP-dependent protease ATP-binding subunit HslUQuickGO ontologyBLASTP
7777517793251575hypothetical proteinBLASTP
7794957807331239ribonuclease BNQuickGO ontologyBLASTP
78114680001518870hypothetical proteinBLASTP
800194800793600trp repressor binding proteinQuickGO ontologyBLASTP
801075801293219hypothetical proteinBLASTP
801482802264783exodeoxyribonuclease IIIQuickGO ontologyBLASTP
802257803027771hypothetical proteinBLASTP
80316480339122850S ribosomal protein L31QuickGO ontologyBLASTP
8035188047531236malate oxidoreductaseQuickGO ontologyBLASTP
8049648062561293major facilitator family transporter transporterQuickGO ontologyBLASTP
8062378075141278major facilitator family transporter transporterQuickGO ontologyBLASTP
807543808361819DNA adenine methylaseQuickGO ontologyBLASTP
8085328097941263tryptophantyrosine permeaseQuickGO ontologyBLASTP