Pre_GI Gene

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Host: NC_009494 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009494:3119997 Legionella pneumophila str. Corby chromosome, complete genome

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Legionella pneumophila str. Corby is a human isolate. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
31199973120911915UDP-3-O-3-hydroxymyristoyl N-acetylglucosamine deacetylaseQuickGO ontologyBLASTP
312115931223551197cell division protein FtsZQuickGO ontologyBLASTP
312255031237881239ATP-binding cell division protein FtsAQuickGO ontologyBLASTP
31237883124507720cell division protein FtsQQuickGO ontologyBLASTP
312452331256171095D-alanyl-alanine synthetase AQuickGO ontologyBLASTP
31256013126527927UDP-N-acetylenolpyruvoylglucosamine reductaseQuickGO ontologyBLASTP
312653631279451410UDP-N-acetylmuramate--L-alanine ligaseQuickGO ontologyBLASTP
312795531291301176cell division protein FtsWQuickGO ontologyBLASTP
312913631304791344UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseQuickGO ontologyBLASTP
313049331315781086phospho-N-acetylmuramoyl-pentapeptide- transferaseQuickGO ontologyBLASTP
313169331329131221UDP-N-acetylmuramoylalanyl-D-glutamyl-2 6- diaminopimelate-D-alanyl-D-alanyl ligaseQuickGO ontologyBLASTP
31332713134050780cell division protein ZipAQuickGO ontologyBLASTP
313405531375493495chromosome segregation SMC proteinQuickGO ontologyBLASTP
31377243138404681acid phosphataseQuickGO ontologyBLASTP
313850631395671062hypothetical proteinBLASTP
31398773140689813transmembrane proteinQuickGO ontologyBLASTP
31407633141245483transcription elongation factor GreAQuickGO ontologyBLASTP
314125431444033150carbamoyl phosphate synthase large subunitQuickGO ontologyBLASTP