Pre_GI Gene

Some Help

Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:627685 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6255486276922145hydroxamate-type ferrisiderophore receptorQuickGO ontologyBLASTP
6276856287851101hypothetical proteinBLASTP
6290846301721089murein transglycosylase CQuickGO ontologyBLASTP
630343630615273hypothetical proteinBLASTP
6307936319111119adenine DNA glycosylaseQuickGO ontologyBLASTP
632246632965720tRNA guanine-N7--methyltransferaseQuickGO ontologyBLASTP
632965633291327hypothetical proteinBLASTP
633402634328927glutaminaseQuickGO ontologyBLASTP
634440634970531hypothetical proteinBLASTP
634928635173246hypothetical proteinBLASTP
6356696450019333virulence determinantQuickGO ontologyBLASTP
6451916463331143coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
646314646907594putative deoxyribonucleotide triphosphate pyrophosphataseQuickGO ontologyBLASTP
647007647297291hypothetical proteinBLASTP
647294647848555membrane proteinQuickGO ontologyBLASTP
648136648957822pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
649090649788699hypothetical proteinBLASTP
6498086509321125hypothetical proteinBLASTP
6510416521561116agmatine deiminaseQuickGO ontologyBLASTP
652160653044885carbon-nitrogen hydrolaseQuickGO ontologyBLASTP
653224653646423Holliday junction resolvase-like proteinQuickGO ontologyBLASTP
653646654209564hypothetical proteinBLASTP
654325655284960glutathione synthetaseQuickGO ontologyBLASTP