Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:522731 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
522731523624894AraC family transcription regulatorQuickGO ontologyBLASTP
523716524378663DedA family membrane proteinQuickGO ontologyBLASTP
5245715257821212cystathionine beta-lyaseQuickGO ontologyBLASTP
5262615272981038MotATolQExbB proton channel family proteinQuickGO ontologyBLASTP
527308527733426biopolymer transport protein ExbDQuickGO ontologyBLASTP
5278305293711542hypothetical proteinBLASTP
529410529982573hypothetical proteinBLASTP
529966530439474hypothetical proteinBLASTP
530436531206771hypothetical proteinBLASTP
531190532023834hypothetical proteinBLASTP
532020532895876hypothetical proteinBLASTP
5328925341781287type II secretion proteinQuickGO ontologyBLASTP
5341905353171128hypothetical proteinBLASTP
535615536064450outer membrane secretin family proteinQuickGO ontologyBLASTP
536079536933855hypothetical proteinBLASTP
536930537796867hypothetical proteinBLASTP
537848538270423hypothetical proteinBLASTP
538470538928459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
5392815417612481outer membrane usher proteinQuickGO ontologyBLASTP
541779542498720fimbrial chaperone proteinQuickGO ontologyBLASTP
5438405449191080iron-enterobactin transporter periplasmic binding proteinQuickGO ontologyBLASTP
545775546770996hypothetical proteinBLASTP
546862547440579lipoproteinQuickGO ontologyBLASTP
547443547565123hypothetical protein
5476345497302097flagellar biosynthesis protein FlhAQuickGO ontologyBLASTP
5497175508501134flagellar biosynthesis protein FlhBQuickGO ontologyBLASTP
550850551623774flagellar assembly proteinQuickGO ontologyBLASTP