Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:460358 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4603584618841527hypothetical proteinBLASTP
4618894637901902membrane proteinQuickGO ontologyBLASTP
4637744648231050multidrug resistance protein MdtNQuickGO ontologyBLASTP
464833465168336hypothetical proteinBLASTP
465165465365201hypothetical proteinBLASTP
4661314673631233aminotransferaseQuickGO ontologyBLASTP
468822469268447hypothetical proteinBLASTP
469402470028627hypothetical proteinBLASTP
470044470424381translational inhibitor proteinQuickGO ontologyBLASTP
470709471113405translational inhibitor proteinQuickGO ontologyBLASTP
471328471630303hypothetical proteinBLASTP
471890472606717hypothetical proteinBLASTP
472768473700933LysR family regulatory proteinQuickGO ontologyBLASTP
473902474681780transposaseIS proteinQuickGO ontologyBLASTP
4746814757031023transposase for insertion sequence IS100QuickGO ontologyBLASTP
476110476313204hypothetical proteinBLASTP
476247476621375hypothetical proteinBLASTP
476618476776159hypothetical proteinBLASTP
4776954790771383hypothetical proteinBLASTP
479086479556471hypothetical proteinBLASTP
479583480038456hypothetical proteinBLASTP
480055480345291hypothetical proteinBLASTP
480323480661339hypothetical proteinBLASTP