Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:4169353 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
416935341715002148formate dehydrogenase HQuickGO ontologyBLASTP
417152341720805584Fe-4S ferredoxinQuickGO ontologyBLASTP
417210341741182016putative oxidoreductase Fe-S binding subunitQuickGO ontologyBLASTP
41745384175113576putative transcriptional regulatorQuickGO ontologyBLASTP
4175258417533376tRNA-PheQuickGO ontologyBLASTP
417576741783222556enhancing factorQuickGO ontologyBLASTP
41783524178519168hypothetical proteinBLASTP
41792374179539303transposaseQuickGO ontologyBLASTP
41796104179852243hypothetical proteinBLASTP
418000641810401035rhamnose-proton symporterQuickGO ontologyBLASTP
41810154181164150hypothetical proteinBLASTP
41811894182061873transcriptional activator RhaRQuickGO ontologyBLASTP
41821944183015822transcriptional activator RhaSQuickGO ontologyBLASTP
41830194183141123hypothetical proteinBLASTP
418327141848991629rhamnulokinaseQuickGO ontologyBLASTP
418489641861521257L-rhamnose isomeraseQuickGO ontologyBLASTP
41861654186989825rhamnulose-1-phosphate aldolaseQuickGO ontologyBLASTP
418705641882041149alcohol dehydrogenaseQuickGO ontologyBLASTP
41882184188532315hypothetical proteinBLASTP
41887794189327549single-stranded DNA-binding proteinQuickGO ontologyBLASTP
418978541926282844excinuclease ABC subunit AQuickGO ontologyBLASTP