Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:3596000 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35960813596980900transcriptional activator NhaRQuickGO ontologyBLASTP
359711035982941185pH-dependent sodiumproton antiporterQuickGO ontologyBLASTP
359853735996761140chaperone protein DnaJQuickGO ontologyBLASTP
359978836016981911molecular chaperone DnaKQuickGO ontologyBLASTP
36020723602683612hypothetical proteinBLASTP
360297236054192448hypothetical proteinBLASTP
360548936068771389transport proteinQuickGO ontologyBLASTP
36070053607592588molybdenum cofactor biosynthesis protein MogAQuickGO ontologyBLASTP
36076783607836159hypothetical proteinBLASTP
36078803608833954transaldolase BQuickGO ontologyBLASTP
36089003609082183hypothetical proteinBLASTP
36093623610141780hypothetical proteinBLASTP
361095836122471290threonine synthaseQuickGO ontologyBLASTP
36122513613180930homoserine kinaseQuickGO ontologyBLASTP
361318336156422460bifunctional aspartokinase Ihomoserine dehydrogenase IQuickGO ontologyBLASTP
36164743616647174hypothetical proteinBLASTP
36167463617462717two-component response regulatorQuickGO ontologyBLASTP
36176363618103468hypothetical proteinBLASTP