Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:3228500 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
322881832300771260gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
323008732311901104gamma-glutamyl kinaseQuickGO ontologyBLASTP
32313673231768402DNA-binding transcriptional regulator CrlQuickGO ontologyBLASTP
323182832330751248fermentationrespiration switch proteinQuickGO ontologyBLASTP
32332023233660459xanthine-guanine phosphoribosyltransferaseQuickGO ontologyBLASTP
323458932361931605carbohydrate-binding proteinQuickGO ontologyBLASTP
32366533237564912LysR family transcriptional regulatorQuickGO ontologyBLASTP
323943932408991461aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
324101332420711059DNA polymerase IVQuickGO ontologyBLASTP
32424273243374948hypothetical proteinBLASTP
32436183243845228hypothetical proteinBLASTP
324385832449371080thiamine biosynthesis lipoproteinQuickGO ontologyBLASTP
324492132461441224Na-translocating NADH-quinone reductase subunit FQuickGO ontologyBLASTP
32461603246756597Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
32467633247392630Na-translocating NADH-quinone reductase subunit DQuickGO ontologyBLASTP
32473853248185801Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
324817532494161242Na-translocating NADH-quinone reductase subunit BQuickGO ontologyBLASTP
324942032508021383Na-translocating NADH-quinone reductase subunit AQuickGO ontologyBLASTP