Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:321577 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3215773260674491insecticidal toxin complexQuickGO ontologyBLASTP
3261243297173594toxin subunitQuickGO ontologyBLASTP
3297583322592502insecticidal toxinQuickGO ontologyBLASTP
33223933233496hypothetical proteinBLASTP
332495333361867LysR family transcriptional regulatorQuickGO ontologyBLASTP
333622334533912putative DNA-binding transcriptional regulatorQuickGO ontologyBLASTP
334836335039204hypothetical proteinBLASTP
335047335982936p-hydroxybenzoic acid efflux subunit AaeAQuickGO ontologyBLASTP
3359843379391956p-hydroxybenzoic acid efflux subunit AaeBQuickGO ontologyBLASTP
3382063393391134hypothetical proteinBLASTP
339336339674339succinate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
339869340342474ribonucleaseQuickGO ontologyBLASTP
340347340628282ribonuclease inhibitorQuickGO ontologyBLASTP
340740341288549hypothetical proteinBLASTP
3414693428091341peptidase PmbAQuickGO ontologyBLASTP
343094343702609hypothetical proteinBLASTP
343910344296387cytochromeQuickGO ontologyBLASTP
344520344930411nucleoside diphosphate kinase regulatorQuickGO ontologyBLASTP