Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:2939782 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
293978229410621281type II citrate synthaseQuickGO ontologyBLASTP
29411702941748579heat shock protein GrpEQuickGO ontologyBLASTP
29418722942753882inorganic polyphosphateATP-NAD kinaseQuickGO ontologyBLASTP
294284029445011662recombination and repair proteinQuickGO ontologyBLASTP
29446152944956342hypothetical proteinBLASTP
29451062945390285hypothetical proteinBLASTP
29453832945817435hypothetical proteinBLASTP
29459662946460495SsrA-binding proteinQuickGO ontologyBLASTP
29470952947553459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
294777729489761200prophage integraseQuickGO ontologyBLASTP
294905529501431089hypothetical proteinBLASTP
295019429513391146hypothetical proteinBLASTP
29516152951863249hypothetical proteinBLASTP
29527152953038324hypothetical proteinBLASTP
29530602953947888putative DNA-binding prophage proteinQuickGO ontologyBLASTP
29539402954140201transcriptional regulatorQuickGO ontologyBLASTP
29541402954682543prophage proteinQuickGO ontologyBLASTP
29546752955634960prophage DNA primaseQuickGO ontologyBLASTP
295563129567191089regulatory prophage proteinQuickGO ontologyBLASTP
29570682957382315DNA-binding prophage proteinQuickGO ontologyBLASTP
29573882957705318prophage proteinQuickGO ontologyBLASTP
29581202958296177hypothetical proteinBLASTP
295831029593321023transposaseQuickGO ontologyBLASTP
29593322960111780transposaseIS proteinQuickGO ontologyBLASTP
29606582960921264IS1400 transposase AQuickGO ontologyBLASTP
29623142963081768hypothetical proteinBLASTP
29634132963700288LexA regulated proteinQuickGO ontologyBLASTP
29637962964044249hypothetical protein