Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:2731965 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
273196527336651701PTS system fructose-specific transporter subunits IIBCQuickGO ontologyBLASTP
273368027346189391-phosphofructokinaseQuickGO ontologyBLASTP
273461527357481134bifunctional PTS system fructose-specific transporter subunit IIAHPr proteinQuickGO ontologyBLASTP
27360102736465456Mut family proteinQuickGO ontologyBLASTP
27365782737576999ABC transport integral membrane subunitQuickGO ontologyBLASTP
273761227391861575ABC transport ATP-binding subunitQuickGO ontologyBLASTP
273929527403831089periplasmic carbohydrate-binding transport proteinQuickGO ontologyBLASTP
27404992741209711ribose 5-phosphate isomeraseQuickGO ontologyBLASTP
274122927427821554carbohydrate kinaseQuickGO ontologyBLASTP
274278627442821497aldehyde dehydrogenaseQuickGO ontologyBLASTP
274463327457751143hypothetical proteinBLASTP
27457872746737951D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
27467482747563816short chain oxidoreductaseQuickGO ontologyBLASTP
27476322747886255hypothetical proteinBLASTP
274826127495051245tryptophan-specific transport proteinQuickGO ontologyBLASTP
27496092750181573elongation factor PQuickGO ontologyBLASTP
275032127515141194mannonate dehydrataseQuickGO ontologyBLASTP
275211827535901473D-mannonate oxidoreductaseQuickGO ontologyBLASTP
27537342754414681transcriptional regulatory proteinQuickGO ontologyBLASTP
27543862754520135transcriptional regulatory proteinQuickGO ontologyBLASTP