Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:2491427 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
249142724928211395proteaseQuickGO ontologyBLASTP
24934572494347891lipid kinaseQuickGO ontologyBLASTP
24946342495143510hypothetical proteinBLASTP
24953742496261888hypothetical proteinBLASTP
24963232497123801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
24976452498112468membrane proteinQuickGO ontologyBLASTP
24981712498458288hypothetical proteinBLASTP
249848024996881209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
24997132500414702membrane proteinQuickGO ontologyBLASTP
25028472503305459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
250368025052571578GMP synthaseQuickGO ontologyBLASTP
250543725069001464inosine 5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
250707025084491380exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
25085822508806225hypothetical proteinBLASTP
25088552509811957hypothetical proteinBLASTP
251015825116451488GTP-binding protein EngAQuickGO ontologyBLASTP
251179325129741182outer membrane protein assembly complex subunit YfgLQuickGO ontologyBLASTP