Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:2373847 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
23738472374530684two-component system response regulatorQuickGO ontologyBLASTP
237471823759231206HlyD family secretion proteinQuickGO ontologyBLASTP
237592723779632037ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
237821823798641647pyridine nucleotide-disulfide oxidoreductaseQuickGO ontologyBLASTP
237992423813841461permeaseQuickGO ontologyBLASTP
238172123827521032peptidaseQuickGO ontologyBLASTP
23827492382940192hypothetical proteinBLASTP
238297423841551182aminotransferaseQuickGO ontologyBLASTP
238485523862731419hypothetical proteinBLASTP
238650623880501545two-component sensor histidine kinaseQuickGO ontologyBLASTP
23880472388754708two-component response regulatorQuickGO ontologyBLASTP
238913523903671233hypothetical proteinBLASTP
23906122391490879cysteine synthase BQuickGO ontologyBLASTP
239166123927521092sulfatethiosulfate transporter subunitQuickGO ontologyBLASTP
23927422393617876sulfatethiosulfate transporter permeaseQuickGO ontologyBLASTP
23936172394450834sulfatethiosulfate transporter subunitQuickGO ontologyBLASTP
239445023954871038thiosulfate transporter subunitQuickGO ontologyBLASTP