Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:222735 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2227352253292595Clp ATPaseQuickGO ontologyBLASTP
225326226123798hypothetical proteinBLASTP
226120226806687hypothetical proteinBLASTP
2268122282001389hypothetical proteinBLASTP
2282322317653534hypothetical proteinBLASTP
231890232672783hypothetical proteinBLASTP
232579233202624hypothetical proteinBLASTP
2332242356142391Rhs accessory genetic elementQuickGO ontologyBLASTP
235620236078459hypothetical proteinBLASTP
2360712389352865hypothetical proteinBLASTP
2389632403331371hypothetical proteinBLASTP
240870241061192hypothetical proteinBLASTP
241137241361225hypothetical proteinBLASTP
241443241850408transcriptional regulatory proteinQuickGO ontologyBLASTP
242013242189177hypothetical proteinBLASTP
2422112444092199Rhs accessory genetic elementQuickGO ontologyBLASTP