Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:2138625 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
213862521406582034hypothetical proteinBLASTP
21413222141573252hypothetical proteinBLASTP
21418182142327510hypothetical proteinBLASTP
214232921498767548hemolysinQuickGO ontologyBLASTP
215008021517681689hemolysin activator proteinQuickGO ontologyBLASTP
21524212153386966dioxygenase beta subunitQuickGO ontologyBLASTP
215348221546061125dioxygenase alpha subunitQuickGO ontologyBLASTP
215472321562041482putative transporterQuickGO ontologyBLASTP
215698621580831098tartrate dehydrogenaseQuickGO ontologyBLASTP
21581742159115942LlysR family transcriptional regulatory proteinQuickGO ontologyBLASTP
215936221603661005LacI family transcriptional regulatorQuickGO ontologyBLASTP
21604992161491993sugar transport system permeaseQuickGO ontologyBLASTP
21630192163936918sugar binding proteinQuickGO ontologyBLASTP
216411121653371227zinc-binding dehydrogenaseQuickGO ontologyBLASTP
21659202166642723hypothetical proteinBLASTP
21667842167326543hypothetical proteinBLASTP
21675642168502939membrane proteinQuickGO ontologyBLASTP
21688182169342525outer membrane protein XQuickGO ontologyBLASTP
21697472170634888threonine and homoserine efflux systemQuickGO ontologyBLASTP
21706502171147498hypothetical proteinBLASTP
21711702171946777trans-aconitate 2-methyltransferaseQuickGO ontologyBLASTP
21722032172706504DNA starvationstationary phase protection protein DpsQuickGO ontologyBLASTP
217302621741531128hypothetical proteinBLASTP
21747232175466744glutamine ABC transporter periplasmic proteinQuickGO ontologyBLASTP
21755012176157657glutamine ABC transporter permeaseQuickGO ontologyBLASTP
21760672176876810glutamine ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
217710021783921293chemotactic transducerQuickGO ontologyBLASTP