Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:1362471 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
136112513624741350hypothetical proteinBLASTP
13624711362983513pili assembly chaperoneQuickGO ontologyBLASTP
136304513642531209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
13642771364534258pili assembly chaperoneQuickGO ontologyBLASTP
1364837136491276tRNA-AsnQuickGO ontologyBLASTP
136507413663361263integraseQuickGO ontologyBLASTP
136653013678341305salicylate synthase Irp9QuickGO ontologyBLASTP
136786213692501389signal transducerQuickGO ontologyBLASTP
136913513709371803inner membrane ABC-transporter YbtQQuickGO ontologyBLASTP
137092413726361713lipoprotein inner membrane ABC-transporterQuickGO ontologyBLASTP
13728931373852960transcriptional regulator YbtAQuickGO ontologyBLASTP
137404313801506108yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
138023813897299492yersiniabactin biosynthetic proteinQuickGO ontologyBLASTP
138972613908261101yersiniabactin biosynthetic protein YbtUQuickGO ontologyBLASTP
13908381391626789yersiniabactin biosynthetic protein YbtTQuickGO ontologyBLASTP
139163013932071578yersiniabactin siderophore biosynthetic proteinQuickGO ontologyBLASTP
139333813953592022pesticinyersiniabactin receptor proteinQuickGO ontologyBLASTP
13966051397159555hypothetical proteinBLASTP
13972991397484186transcriptional regulatorQuickGO ontologyBLASTP
13975031397667165hypothetical proteinBLASTP
13976731398254582hypothetical proteinBLASTP
13982441398453210hypothetical proteinBLASTP
13986961398809114hypothetical proteinBLASTP
13988531399632780transposaseIS proteinQuickGO ontologyBLASTP
139963214006541023transposaseQuickGO ontologyBLASTP
14011321401317186hypothetical proteinBLASTP
14013331401557225hypothetical proteinBLASTP
14015671401908342sugar ABC transporter ATPaseQuickGO ontologyBLASTP
14017941402684891binding-protein-dependent transport system ATP-binding proteinQuickGO ontologyBLASTP
14027091403536828binding-protein-dependent transport system inner membrane proteinQuickGO ontologyBLASTP
14035291404389861binding-protein-dependent transport system inner membrane proteinQuickGO ontologyBLASTP