Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:1258396 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12583961259175780transposaseIS proteinQuickGO ontologyBLASTP
12592141259675462transcriptional activatorQuickGO ontologyBLASTP
125968712610721386two-component system sensor proteinQuickGO ontologyBLASTP
12613491261771423decarboxylaseQuickGO ontologyBLASTP
12618261262296471hypothetical proteinBLASTP
126250912635821074hypothetical proteinBLASTP
12643731265278906hypothetical proteinBLASTP
12652841266216933hypothetical proteinBLASTP
12662031267153951hypothetical proteinBLASTP
12674941268174681dehydrogenaseQuickGO ontologyBLASTP
12682791268938660hypothetical proteinBLASTP
12690731269711639hypothetical proteinBLASTP
126995812720692112hypothetical proteinBLASTP
127264712748092163hypothetical proteinBLASTP
127485512760631209transposase for the IS285 insertion elementQuickGO ontologyBLASTP