Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:1205900 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12051001205903804hypothetical proteinBLASTP
12059001206871972hypothetical proteinBLASTP
12070641207828765copper homeostasis protein CutCQuickGO ontologyBLASTP
12080601208635576hypothetical proteinBLASTP
12086651208832168hypothetical proteinBLASTP
120923412109641731arginyl-tRNA synthetaseQuickGO ontologyBLASTP
121119512158054611hemolysinQuickGO ontologyBLASTP
121595512176161662hemolysin activator proteinQuickGO ontologyBLASTP
121807212196071536membrane proteinQuickGO ontologyBLASTP
121987412214841611oxidoreductaseQuickGO ontologyBLASTP
12214921222076585ribosomal-protein-S5-alanine N-acetyltransferaseQuickGO ontologyBLASTP
122237012235751206multidrug resistance protein MdtHQuickGO ontologyBLASTP
12239701224533564hypothetical proteinBLASTP
12249871225547561hypothetical proteinBLASTP
12255841226321738putative hydrolaseQuickGO ontologyBLASTP
1226610122669990tRNA-SerQuickGO ontologyBLASTP
122695612280681113transcriptional regulatory proteinQuickGO ontologyBLASTP
12280821228912831hypothetical proteinBLASTP