Pre_GI Gene

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Host: NC_009381 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009381:1064227 Yersinia pestis Pestoides F chromosome, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10642271064769543intracellular septation protein AQuickGO ontologyBLASTP
10648491065298450acyl-CoA thioester hydrolaseQuickGO ontologyBLASTP
106544610666541209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
10666901067448759transport protein TonBQuickGO ontologyBLASTP
10677491068045297YciI-like proteinQuickGO ontologyBLASTP
10682681068513246hypothetical proteinBLASTP
10686291068892264hypothetical proteinBLASTP
10690101069138129hypothetical proteinBLASTP
10691131069652540attachment invasion locus proteinQuickGO ontologyBLASTP
107069910721591461cardiolipin synthetaseQuickGO ontologyBLASTP
10722941072647354dsDNA-mimic proteinQuickGO ontologyBLASTP
10729461073161216hypothetical proteinBLASTP
107372210747231002oligopeptide transporter ATP-binding proteinQuickGO ontologyBLASTP
107472010757211002oligopeptide transporter ATP-binding proteinQuickGO ontologyBLASTP
10757331076638906oligopeptide transport system permeaseQuickGO ontologyBLASTP
10766571077577921oligopeptide transporter permeaseQuickGO ontologyBLASTP
107766410793011638periplasmic oligopeptide-binding proteinQuickGO ontologyBLASTP
10801381080782645hypothetical proteinBLASTP
108158910842642676bifunctional acetaldehyde-CoAalcohol dehydrogenaseQuickGO ontologyBLASTP
10850151085605591thymidine kinaseQuickGO ontologyBLASTP
10863551086783429global DNA-binding transcriptional dual regulator H-NSQuickGO ontologyBLASTP
108679510880031209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
108852010898661347nucleotide sugar dehydrogenaseQuickGO ontologyBLASTP