Pre_GI Gene

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Host: NC_009378 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009378:62215 Yersinia pestis Pestoides F plasmid MT, complete sequence

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6177562218444hypothetical proteinBLASTP
62215657393525DNA polymerase IIIQuickGO ontologyBLASTP
65920671551236porphyrin biosynthetic proteinQuickGO ontologyBLASTP
67252696182367porphyrin biosynthetic proteinQuickGO ontologyBLASTP
6972869940213hypothetical proteinBLASTP
7020370589387hypothetical proteinBLASTP
70584716871104integraseQuickGO ontologyBLASTP
7244572957513F1 capsule antigenQuickGO ontologyBLASTP
73038755392502F1 capsule anchoring proteinQuickGO ontologyBLASTP
7556476340777F1 chaperone proteinQuickGO ontologyBLASTP
7665077573924F1 operon positive regulatory proteinQuickGO ontologyBLASTP
7808978394306C-type natriuretic proteinQuickGO ontologyBLASTP
7854078755216hypothetical proteinBLASTP
78915802371323DNA ligaseQuickGO ontologyBLASTP
8027280748477hypothetical proteinBLASTP
8083081624795hypothetical proteinBLASTP
8187782599723hypothetical proteinBLASTP
82633838411209transposaseQuickGO ontologyBLASTP
83962867812820conjugal transfer mating pair stabilization protein TraGQuickGO ontologyBLASTP
86781881541374conjugal transfer pilus assembly protein TraHQuickGO ontologyBLASTP
8815188696546conjugal transfer protein TrbBQuickGO ontologyBLASTP
8868688934249conjugal transfer pilin chaperone TraQQuickGO ontology
8895189700750conjugal pilus assembly protein TraFQuickGO ontologyBLASTP