Pre_GI Gene

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Host: NC_009378 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009378:106193 Yersinia pestis Pestoides F plasmid MT, complete sequence

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1061931114335241conjugal transfer nickasehelicase TraIQuickGO ontologyBLASTP
111435112172738conjugative transfer fimbrial acetylation proteinQuickGO ontologyBLASTP
112239112958720conjugal transfer fertility inhibition protein FinOQuickGO ontologyBLASTP
112951113742792hypothetical proteinBLASTP
113890114444555endonucleaseQuickGO ontologyBLASTP
114854115717864replication proteinQuickGO ontologyBLASTP
1169241179461023transposaseQuickGO ontologyBLASTP
118145118432288hypothetical proteinBLASTP
118515118715201transposaseQuickGO ontologyBLASTP
119322119777456hypothetical proteinBLASTP
1200221217851764toxinQuickGO ontologyBLASTP
121863122351489hypothetical proteinBLASTP
123090123365276hypothetical proteinBLASTP
123388124329942hypothetical proteinBLASTP
124395125015621resolvaseQuickGO ontologyBLASTP
125541125768228hypothetical proteinBLASTP
1260701272751206partitioning protein AQuickGO ontologyBLASTP
127272128243972partitioning protein BQuickGO ontologyBLASTP
128380128526147hypothetical proteinBLASTP
1286281300191392DNA-binding proteinQuickGO ontologyBLASTP
130181130489309hypothetical proteinBLASTP
130882131559678putative methylaseQuickGO ontologyBLASTP
131559131780222hypothetical proteinBLASTP
131791132210420hypothetical proteinBLASTP
132264133043780hypothetical proteinBLASTP
133442133948507antirestriction proteinQuickGO ontologyBLASTP
134661134891231hypothetical proteinBLASTP
1349641369732010DNA-binding proteinQuickGO ontologyBLASTP