Pre_GI Gene

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Host: NC_008600 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008600:3724312 Bacillus thuringiensis str. Al Hakam, complete genome

Host Lineage: Bacillus thuringiensis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: Produces insect toxin. This organism, also known as BT, is famous for the production of an insecticidal toxin. The bacterium was initially discovered as a pathogen of various insects and was first used as an insecticidal agent in the early part of this century. This organism, like many other Bacilli, is found in the soil, where it leads a saprophytic existence, but becomes an opportunistic pathogen of insects when ingested. The specific activity of the toxin towards insects and its lack of toxicity to animals has made this organism a useful biocontrol agent. The delta-endotoxin, which is produced during the sporulation part of the life cycle, causes midgut paralysis and disruption of feeding by the infected insect host. The delta-endotoxin, which is produced during the sporulation part of the life cycle, causes midgut paralysis and disruption of feeding by the infected insect host. The delta-endotoxin, which is produced during the sporulation part of the life cycle, causes midgut paralysis and disruption of feeding by the infected insect host. The presence of a parasporal crystal, which is outside the exosporium of the endospore, is indicative of production of the toxin, and serves as a marker for this species.Activation of the toxin typically requires a high pH environment such as the alkaline environments in insect midguts followed by proteolysis. Various toxin genes specific for a variety of insects have been studied, and many are now being used in genetically modified plants which have been engineered to produce the toxin themselves, eliminating the need to produce sufficient amounts of B. thuringiensis spores.


This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
372431237253821071proline dipeptidaseQuickGO ontologyBLASTP
37254673725991525hypothetical proteinBLASTP
372685537283241470hypothetical proteinBLASTP
37288733729250378transposaseQuickGO ontologyBLASTP
37293853730125741transposaseQuickGO ontologyBLASTP
37301823730832651orotate phosphoribosyltransferaseQuickGO ontologyBLASTP
37308113731554744orotidine 5-phosphate decarboxylaseQuickGO ontologyBLASTP
37315123732441930dihydroorotate dehydrogenaseQuickGO ontologyBLASTP
37324383733217780dihydroorotate dehydrogenase electron transfer subunitQuickGO ontologyBLASTP
373321437364323219carbamoyl-phosphate synthaseQuickGO ontologyBLASTP
373641737375381122carbamoyl-phosphate synthase small subunitQuickGO ontologyBLASTP
373751137387971287dihydroorotaseQuickGO ontologyBLASTP
37387813739701921aspartate carbamoyltransferaseQuickGO ontologyBLASTP
373984437411601317uracil permeaseQuickGO ontologyBLASTP
37412743741816543uracil phosphoribosyltransferaseQuickGO ontologyBLASTP
37420193742927909ribosomal large subunit pseudouridine synthase DQuickGO ontologyBLASTP