Pre_GI Gene

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Host: NC_008262 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008262:904000 Clostridium perfringens SM101, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9041159051191005iron compound ABC transporter permease proteinQuickGO ontologyBLASTP
9051199061411023iron compound ABC transporter permease proteinQuickGO ontologyBLASTP
906141906917777ironIII dicitrate transport permease-like protein yusVQuickGO ontologyBLASTP
907271907786516MutTnudix family protein putativeQuickGO ontologyBLASTP
907938908519582PAP2 family proteinQuickGO ontologyBLASTP
9088779098991023ISCpe7 transposaseQuickGO ontologyBLASTP
910025910765741hypothetical proteinBLASTP
911480911824345FliB domain proteinQuickGO ontologyBLASTP
912005912472468hypothetical proteinBLASTP
9126639145371875sensory box proteinhistidinol phosphate phosphatase family proteinQuickGO ontologyBLASTP
9148189166501833cymH proteinQuickGO ontologyBLASTP
9168959181781284hypothetical proteinBLASTP
918465918968504hypothetical proteinBLASTP
919336919881546hypothetical proteinBLASTP
919919920539621hypothetical proteinBLASTP
920802921746945Periplasmic binding protein familyQuickGO ontologyBLASTP
9218459228581014iron compound ABC transporter permease proteinQuickGO ontologyBLASTP
9228629238751014ferrichrome transport system permease proteinQuickGO ontologyBLASTP
923940924722783Ferrichrome transport ATP-binding protein fhuCQuickGO ontologyBLASTP
925034925471438acetyltransferase GNAT familyQuickGO ontologyBLASTP
925599925814216hypothetical proteinBLASTP
925807926055249hypothetical proteinBLASTP