Pre_GI Gene

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Host: NC_008262 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008262:2433979 Clostridium perfringens SM101, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24339792434941963oxidoreductase pyridine nucleotide-disulphide familyQuickGO ontologyBLASTP
24349732435545573predicted Transcriptional regulatorQuickGO ontologyBLASTP
243572624376091884sulfataseQuickGO ontologyBLASTP
243774324392661524putative lipoproteinQuickGO ontologyBLASTP
243928324406981416sensor histidine kinase HpkAQuickGO ontologyBLASTP
24408792441562684DNA-binding response regulatorQuickGO ontologyBLASTP
2441882244195675tRNA-AsnQuickGO ontology
2445015244509177tRNA-IleQuickGO ontology
2445097244517276tRNA-AlaQuickGO ontologyBLASTP
24473272447896570probable chromate transport protein putativeQuickGO ontologyBLASTP
24478832448434552chromate transport proteinQuickGO ontologyBLASTP
244863924500901452aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
2450271245034777tRNA-ArgQuickGO ontologyBLASTP
2450396245046974tRNA-GlyQuickGO ontologyBLASTP
2450473245054775tRNA-GlyQuickGO ontology
2450571245065484tRNA-LeuQuickGO ontology
2450665245074076tRNA-LysQuickGO ontologyBLASTP
2450748245082275tRNA-GlnQuickGO ontology
2450828245090376tRNA-HisQuickGO ontology
2450908245098477tRNA-ArgQuickGO ontologyBLASTP
2451020245109374tRNA-GlyQuickGO ontologyBLASTP
2451098245117376tRNA-ProQuickGO ontologyBLASTP
2451179245125577tRNA-ArgQuickGO ontologyBLASTP
2451331245140474tRNA-GlyQuickGO ontologyBLASTP
2451409245148375tRNA-GlyQuickGO ontology
2451507245159084tRNA-LeuQuickGO ontology
2451601245167676tRNA-LysQuickGO ontologyBLASTP
2451696245177176tRNA-LysQuickGO ontologyBLASTP
2451778245185275tRNA-GlnQuickGO ontology
2451856245193176tRNA-HisQuickGO ontology
2451936245201277tRNA-ArgQuickGO ontologyBLASTP
2452092245216675tRNA-GlyQuickGO ontology
2452171245224575tRNA-ProQuickGO ontology
24524552452925471SerThr protein phosphatase family proteinQuickGO ontologyBLASTP
24529372453551615non-canonical purine NTP pyrophosphatase rdgBHAM1 familyQuickGO ontologyBLASTP
24535532454299747ribonuclease PHQuickGO ontologyBLASTP
245451224562241713hypothetical proteinBLASTP
245649324579831491Bacterial extracellular solute-binding proteins family 5 superfamilyQuickGO ontologyBLASTP
24581932458657465hypothetical protein
24587812459104324hypothetical protein
245913924611271989DNA ligase NAD-dependentQuickGO ontologyBLASTP
246116524634202256ATP-dependent DNA helicase PcrAQuickGO ontologyBLASTP
24639192464149231hypothetical protein
24641662464714549hypothetical protein
2465344246606372016S pseudouridylate synthaseQuickGO ontologyBLASTP
246643724684822046two component regulator three Y motif proteinQuickGO ontologyBLASTP