Pre_GI Gene

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Host: NC_008262 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008262:1950205 Clostridium perfringens SM101, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
195020519512421038probable permeaseQuickGO ontologyBLASTP
19512681951741474PRC-barrel domain proteinQuickGO ontologyBLASTP
195202319531021080tRNA 5-methylaminomethyl-2-thiouridylate-methyltransferaseQuickGO ontologyBLASTP
19531211953555435nifU proteinQuickGO ontologyBLASTP
195355819547541197cysteine desulfuraseQuickGO ontologyBLASTP
19547471955208462uncharacterized conserved protein of YjeBRRF2 familyQuickGO ontologyBLASTP
195533819565851248ATPase AAA familyQuickGO ontologyBLASTP
19567871957656870response regulatory protein sensory transduction systemQuickGO ontologyBLASTP
19578721958300429MOSC domain putativeQuickGO ontologyBLASTP
19583031959274972molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
195942019604331014molybdenum cofactor biosynthesis protein putativeQuickGO ontologyBLASTP
19605521961148597molybdopterin-guanine dinucleotide biosynthesis protein-like proteinQuickGO ontologyBLASTP
196119219624121221molybdenum cofactor biosynthesis protein MoeAQuickGO ontologyBLASTP
19627161963186471molybdopterin-guanine dinucleotide biosynthesis protein BQuickGO ontologyBLASTP
196328919645121224nitrate reductase NADH oxidase subunitQuickGO ontologyBLASTP
19645141964927414nitrate reductase electron transfer subunitQuickGO ontologyBLASTP
196494019670182079nitrate reductase catalytic subunitQuickGO ontologyBLASTP
196738919686661278putative FAD dependent oxidoreductaseQuickGO ontologyBLASTP
19686981969678981oxidoreductase family proteinQuickGO ontologyBLASTP