Pre_GI Gene

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Host: NC_008262 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008262:1835613 Clostridium perfringens SM101, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
183561318371481536HD superfamily hydrolase YMDAQuickGO ontologyBLASTP
183749618385541059recA proteinQuickGO ontologyBLASTP
18386901839280591CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
183926418406011338MiaB-like tRNA modifying enzyme YliGQuickGO ontologyBLASTP
184067018430602391DNA translocase FtsKQuickGO ontologyBLASTP
18431921843881690clp proteaseQuickGO ontologyBLASTP
184393518451311197aspartokinaseQuickGO ontologyBLASTP
18451451845420276PRC-barrel domain proteinQuickGO ontologyBLASTP
184555518476632109polyribonucleotide nucleotidyltransferaseQuickGO ontologyBLASTP
18477551848018264ribosomal protein S15QuickGO ontologyBLASTP
18481341849063930riboflavin biosynthesis protein RibFQuickGO ontologyBLASTP
18490671849951885tRNA pseudouridine synthase bQuickGO ontologyBLASTP
18499551850908954DHH subfamily 1 proteinQuickGO ontologyBLASTP
18509121851262351ribosome-binding factor AQuickGO ontologyBLASTP
185128418533232040translation initiation factor IF-2QuickGO ontologyBLASTP
18533541853656303Ribosomal protein L7Ae superfamilyQuickGO ontologyBLASTP
18536491853915267hypothetical proteinBLASTP
185394318550431101N utilization substance protein AQuickGO ontologyBLASTP