Pre_GI Gene

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Host: NC_008262 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008262:1721496 Clostridium perfringens SM101, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17214961721603108hypothetical protein
17221951723190996K-dependent NaCa exchanger related-proteinQuickGO ontologyBLASTP
172331617243381023ISCpe7 transposaseQuickGO ontologyBLASTP
172460217256811080DNA polymerase IVQuickGO ontologyBLASTP
17258231726410588peptidyl-prolyl cis-trans isomerase cyclophilin-typeQuickGO ontologyBLASTP
17266321727036405hypothetical protein
17271531727983831HAD hydrolase IIB familyQuickGO ontologyBLASTP
17282791728992714phage shock protein AQuickGO ontologyBLASTP
17290781729779702putative lipoproteinQuickGO ontology
17299271730592666hypothetical protein
173073017330662337putative glutamate--cysteine ligaseputative amino acid ligaseQuickGO ontologyBLASTP
17334621734379918Patatin-like phospholipase familyQuickGO ontologyBLASTP
173452617358151290permeaseQuickGO ontologyBLASTP
17360671736435369hypothetical proteinBLASTP
17366381737591954sugar ABC transporterQuickGO ontologyBLASTP
173759117386881098ABC transporter permease proteins-like protein lmo1390QuickGO ontologyBLASTP
173867817402131536sugar ABC transporter ATP binding protein alr5362QuickGO ontologyBLASTP